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Potential mechanism of action of 5,4’-dihydroxy-6,7,8,3’-tetramethoxyflavone on human liver and lung cancer cells. (A) Mitochondrial membrane potential; ROS production in NCI-H460 (B) and HepG2 (C) cells by DCFH-DA essay. The caspase activity in the NCI-H460 (D) and HepG2 (E) cells treated with AB2. Expression of active caspase-3 protein on NCI-H460 (F) and HepG2 (G) cells was confirmed by Western blot analysis, * mean significant difference (p < 0.05) compared to control.
