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Levels of anti-LtxA antibodies according to isotype in the study groups. Levels of anti-LtxA IgM (A), anti-LtxA IgG (B) and anti-LtxA IgA (C) in controls, n = 567; periodontitis healthy individuals (PH), n = 73; pre-symptomatic individuals (pre-sympt.i.), n = 526; early RA, n = 231; and established RA, n = 168.
