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. 2020 Jul 10;10(3):2045894020928300. doi: 10.1177/2045894020928300

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — The miRNA-target regulatory network. Red triangles, green arrows, and blue circles represent up-regulated miRNAs, down-regulated miRNAs, and target genes, respectively (a); the protein–protein interaction network. Red circles and green diamonds represent the target genes of up-regulated miRNAs and down-regulated miRNAs, respectively. The higher the degree of a node, the larger the node is (b). The modules (a), (b), (c), and (d) identified from the protein–protein interaction network. Red circles and green diamonds represent the target genes of up-regulated miRNAs and down-regulated miRNAs, respectively. The higher the degree of a node, the larger the node is (c). The transcription factor (TF)-target regulatory network. Red circles and green diamonds represent the target genes of up-regulated miRNAs and down-regulated miRNAs, respectively. Orange hexagons stand for TFs. The higher the degree of a node, the larger the node is (d).