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. 2020 Jun 12;12(6):544. doi: 10.3390/pharmaceutics12060544

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Accumulative DTX amount of DTX, DTX@PLC, DTX-SME, and DTX@PLC-SME across the intestinal segment (jejunum) for 240 min. The dotted marks and dashed lines indicate the observed accumulative amounts and the slopes from linear regression analysis with observed values, respectively. Values are presented as mean ± SD (n = 4). (B) Apparent permeability coefficients (P_app) of DTX, DTX@PLC, DTX-SME, and DTX@PLC-SME investigated with non-everted gut sac model. Values are expresses as the mean ± SD (n = 4). * p < 0.05 versus DTX. ^# p < 0.05 versus DTX@PLC. ^$ p < 0.05 versus DTX-SME.