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. 2020 May 21;245(12):999–1008. doi: 10.1177/1535370220928275

Figure 2.

Figure 2.

Histopathology of lipid layer-composing exocrine glands in mice. (a) Meibomian glands (MGs) in the upper tarsal plate. Sebaceous gland cells form clusters beneath the conjunctival epithelium (CE). Melanin pigments indicated by arrowheads are observed between and around acinar cells. CS: conjunctival sac; Cor: cornea. HE staining. Bars = 100 µm. (b) Harderian glands (HGs) in the third eyelid. Acini of HGs are composed of clear glandular epithelial cells containing numerous minute lipids in their abundant cytoplasm. Some acini include porphyrins in their lumens. Arrowheads point to porphyrin. Smaller acinar epithelial cells are observed in BXSB-Yaa at 20 and 28 weeks. HE staining. Bars = 100 µm. (c) MG acinus density. (d) The size of one acinus in HGs. BXSB: BXSB/MpJ. BXSB-Yaa: BXSB/MpJ-Yaa Each bar represents the mean ± SE (n = 4). *Significant strain difference at the same age, Mann–Whitney U test. †Significant difference from the other groups, Kruskal–Wallis test followed by the Scheffe’s method. (A color version of this figure is available in the online journal.)