Figure 3.

Histopathology of water layer-composing exocrine glands in mice. (a) Extraorbital lacrimal glands (ELGs). Each acinus is composed of serous cells and a small lumen. Mononuclear cells (arrowheads) are observed around the ducts (arrows). Smaller acini are observed in BXSB-Yaa at 20 and 28 weeks. HE staining. Bars = 100 µm. (b) Intraorbital lacrimal glands (ILGs). Histological characteristics are similar to those of ELG. These glands are separated into smaller lobules. Smaller acini are observed in BXSB-Yaa at 20 and 28 weeks. HE staining. Bars = 100 µm. (c) Size of one acinus in ELGs. (d) Size of one acinus in ILGs. BXSB: BXSB/MpJ. BXSB-Yaa: BXSB/MpJ-Yaa Each bar represents the mean ± SE (n = 4). *Significant strain difference at the same age, Mann–Whitney U test. ^†Significant from the other groups, Kruskal–Wallis test followed by the Scheffe’s method. (A color version of this figure is available in the online journal.)