Table 1.

Correlations among tear volume, autoimmune disease indices, and altered tear-secreting tissue morphologies.

			Tear volume	Lipid		Water		Mucin	Cornea
				MG	HG	ELG	ILG	Conjunctiva
All	Tear volume	ρ	1.000	−0.219	0.161	–0.009	0.323	–0.050	0.015
		P	–	0.304	0.453	0.968	0.124	0.816	0.944
	S/B	ρ	−0.184	−0.481*	−0.591**	−0.418*	−0.475*	0.176	−0.157
		P	0.391	0.017	0.002	0.042	0.019	0.412	0.465
	Anti-dsDNA antibody	ρ	−0.085	−0.619**	−0.436*	−0.388	−0.286	−0.109	−0.117
		P	0.694	0.001	0.033	0.061	0.175	0.612	0.588
BXSB-Yaa	Tear volume	ρ	1.000	−0.360	0.455	0.161	0.587*	−0.098	−0.077
		P	–	0.25	0.138	0.618	0.045	0.762	0.812
	S/B	ρ	−0.930**	0.322	−0.664*	−0.315	−0.608*	0.119	0.182
		P	0	0.308	0.018	0.319	0.036	0.713	0.572
	Anti-dsDNA antibody	ρ	−0.657*	0.265	−0.126	−0.224	−0.545	−0.420	0.420
		P	0.02	0.405	0.697	0.484	0.067	0.175	0.175

Note: Spearman’s rank correlation coefficients *P < 0.05, **P < 0.01.

All mice (n = 24), BXSB-Yaa: BXSB/MpJ-Yaa (n = 12).

S/B: the ratio of spleen weight to body weight; Tear: tear volume; MG: MG acinus density; HG: the size of one acinus in the Harderian gland; ELG: the size of one acinus in the extraorbital lacrimal gland; ILG: the size of one acinus in the intraorbital lacrimal gland; conjunctiva: the goblet cell density in the conjunctiva epithelium; cornea: the thickness of the corneal anterior epithelium; -: not determined.