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. 2020 Jun 19;8(6):925. doi: 10.3390/microorganisms8060925

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of sevelamer on hepatic lipid metabolism in CDHF-fed mice. (A-F) Relative mRNA expression levels of (A) Srebf1, (B) Mlxipl, (C) Fas, (D) Acc1, (E) Ppara, and (F) Pparg in the liver of experimental groups. The mRNA expression levels were measured by quantitative RT-PCR (qRT-PCR), and 18s rRNA was used as internal control for qRT-PCR. Quantitative values are indicated as ratios to the values of CSNF + veh group. Vehicle (veh), sevelamer (sev), choline-sufficient amino acid containing normal fat (CSNF), choline-deficient, L-amino acid-defined containing high-fat (CDHF). Data are mean ± SD (n = 10). * p < 0.05, indicating a significant difference between groups. ** p < 0.01, indicating a significant difference between groups.