Figure 5.

An overview of coumarin activity in the BioMap panel. There was no cytotoxicity observed at any concentrations tested. Antiproliferation is indicated by a gray arrow. Biomarkers are annotated if: (1) 2 or more consecutive concentrations are changed in the same direction relative to vehicle controls, (2) at least 1 readout is outside of the significance envelope, and (3) at least 1 concentration has an effect size > 20%versus vehicle controls. A lowest observed effect level (LOEL) was defined for each cell system as the lowest concentration at which a biomarker was significantly changed outside of the vehicle envelope and a dose-response was observed.