Table 1.

Lesion incidences within groups and severity scores for histopathologic lesions in zibotentan-treated and vehicle control animals.

	Intact, Vehicle		Castrated, Vehicle		Intact, Treated		Castrated, Treated
	Ave Severity	Group Incidence	Ave Severity	Group Incidence	Ave Severity	Group Incidence	Ave Severity	Group Incidence
Inflammation, chronic-active	0.6	40%	2.22	100%	2.38	100%	3.7	100%
NALT hyperplasia	1	70%	2.33	100%	1.13	75%	2.6	100%
Olfactory, accumulation, hyaline droplet	0.5	40%	1.89	89%	2.5	100%	2.9	100%
Olfactory epithelium, atrophy	0.7	50%	1.33	67%	2.5	100%	2.6	100%
Olfactory, metaplasia, respiratory	0	0%	0.44	22%	0.88	50%	2.4	100%
Olfactory epithelium, necrosis	0	0%	0	0%	0.75	38%	1.4	70%
Olfactory, nerve atrophy	0.5	30%	1.78	78%	3	100%	4	100%
Respiratory, accumulation, hyaline droplet	1.1	80%	2.44	89%	2.25	100%	3.4	100%
Respiratory epithelium, hyperplasia	0.7	60%	2.33	100%	1.25	88%	3.1	100%
Respiratory, metaplasia, squamous	0	0%	0	0%	0	0%	0.5	40%
Respiratory epithelium, atrophy	0.2	20%	0.44	22%	0.75	50%	1.5	100%
Respiratory epithelium, necrosis	0	0%	0.78	33%	0.14	13%	0.3	30%
Nasolacrimal duct, hyperplasia, squamous	1	80%	1	56%	1.75	100%	1.4	60%
Luminal protein	0.6	50%	0.78	67%	1.38	75%	1.8	80%

0 = no lesion; 1 = minimal; 2 = mild; 3 = moderate; 4 = severe