Table 3.
Associated p-values for histopathologic lesions correlation with castration and zibotentan treatment.
| Fisher's exact p value for reproductive status | Relative risk (RR) and confidence interval (CI) for reproductive status | Fisher's exact p value for treatment status | Relative risk (RR) and confidence interval (CI) for treatment status | |
|---|---|---|---|---|
| Inflammation, chronic-active | 0.0164* |
1.417 1.229 to 1.552 |
>0.9999 |
1 0.8241 to 1.213 |
| NALT hyperplasia | 0.0404* | 1.308 1.059 to 1.625 |
>0.9999 | 1 0.7411 to 1.349 |
| Olfactory, accumulation, hyaline droplet | 0.0806 |
1.342 0.9965 to 2.038 |
0.0191* |
1.5 1.5 to 1.503 |
| Olfactory epithelium, atrophy | 0.6843 |
1.101 0.7747 to 1.642 |
0.0076* |
1.636 1.612 to 1.819 |
| Olfactory, metaplasia, respiratory | 0.0228* |
2.684 1.174 to 6.935 |
0.0001* |
7 2.62 to 25.5 |
| Olfactory epithelium, necrosis | 0.2742 |
2.088 0.705 to 6.678 |
0.0003* |
∞ 2 to ∞ |
| Olfactory, nerve atrophy | 0.1138 | 1.383 0.9656 to 2.202 |
0.0029* | 1.8 1.771 to 1.866 |
| Respiratory, accumulation, hyaline droplet | >0.9999 |
1.007 0.7931 to 1.308 |
0.4857 |
1.25 0.9171 to 1.267 |
| Respiratory epithelium, hyperplasia | 0.0952 |
1.214 0.9912 to 1.224 |
0.2286 |
1.2 0.9719 to 1.218 |
| Respiratory, metaplasia, squamous | 0.1062 |
∞ 1.045 to ∞ |
0.1039 |
∞ 1 to ∞ |
| Respiratory epithelium, atrophy | 0.2021 |
1.64 0.8095 to 3.597 |
0.0067* |
3.25 1.45 to 8.296 |
| Respiratory epithelium, necrosis | 0.0918 | 5.368 0.9899 to 32.51 |
>0.9999 | 1.333 0.3788 to 4.793 |
| Nasolacrimal duct, hyperplasia, squamous | 0.0438* |
0.6711 0.4318 to 0.9437 |
>0.9999 |
1 0.6733 to 1.485 |
| Luminal protein | 0.7206 | 1.139 0.7248 to 1.874 |
0.4705 | 1.273 0.8126 to 2.098 |
*
Statistically significant values at p < 0.05