Table 1. In Vitro Antimalarial Activity against CQ-Susceptible (3D7) and CQ-Resistant (W2) P. falciparum Strains after the 1st (48 h) and 2nd (96 h) Life Cycle.
| IC50 (nM)a 1st life Cycle (48 h) |
IC50 (nM)a 2nd life Cycle (96 h) |
|||||
|---|---|---|---|---|---|---|
| 3D7 | W2 | 3D7 | W2 | RI | Log P | |
| 1 | 359.40 ± 1.15 | nd | 311.30 ± 1.07 | nd | 6.31 | |
| 2 | 25.52 ± 4.45 | 63.17 ± 1.2 | 13.52 ± 0.2 | 30.64 ± 1.07 | 2.47 | 5.02 |
| 3 | 37.63 ± 1.18 | 146.2 ± 1.19 | 14.83 ± 1.09 | 33.39 ± 1.11 | 3.88 | 4.29 |
| 4 | 9109.00 ± 1.18 | nd | 4786.00 ± 1.05 | nd | 3.81 | |
| CFX | 45350.00 ± 1.18 | 37080.00 ± 1.04 | 26260.00 ± 0.99 | 22850.00 ± 1.04 | 1.62 | 1.32 |
| CQ | 12.56 ± 0.66 | 430.60 ± 1.09 | nd | nd | 34.2 | 3.93 |
a
IC50 values are from a single experiment with the duplicate sample. CQ = chloroquine, CFX = ciprofloxacin: Resistance Indices (RI) = IC50 (W2)/IC50(3D7) after first life cycle were 0calculated using ChemDraw ultra 7.0; nd = not determined.