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. 2020 Jun 12;11(7):1392–1401. doi: 10.1021/acsmedchemlett.0c00070

Figure 2.

Figure 2

Compound 6 inhibits pyroptotic cell death in macrophages. (A) Confocal microscopy images of murine primary macrophage, stained with propidium iodide (PI). (B) In a dose-dependent manner, compound 6 inhibited Niggericin induced IL-β release and cell death (measured as LDH release and Alamar blue assay) in murine primary macrophage. (C) Pyroptotic cell death in human THP cells was assessed through LDH release and PI uptake. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. LDH, Alamar blue assay and PI data are means ± SE and are representative of ≥3 experimental replicates.