Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reagents and conditions: (i) Cs2CO3, DMF, 2 h, 100%; (ii) NH4OAc, toluene, 110 °C, 3 h; (iii) Boc2O, DMAP, CH2Cl2, rt, 3 h, 92% two steps; (iv) EDCI, HOBT, MMP, MeONHMe·HCl, DMF/DCM, overnight, 72%; (v) CH2=CHCH2CH2MgBr, THF, 60 °C, 3 h, 100%; (vi) UMICOREM71 SIPR, toluene, 55 °C, 3 h, 78%; (vii) TFA/CH2Cl2, rt, 92%; (viii) Pd/C, H2, MeOH, 92%; (ix) 1-methylazetidine-3-carboxylic acid, MMP, COMU, CH2Cl2/DMF, 79%.
