Table 4. HDACi 10 Selectivity over HDAC Enzymes.
| Comp # | HDAC1 IC50 (nM) | HDAC2 IC50 (nM) | HDAC3 IC50 (nM) | HDAC4 IC50 (μM) | HDAC5 IC50 (μM) | HDAC6 IC50 (μM) | HDAC7 IC50 (μM) | HDAC8 IC50 (nM) | HDAC11 IC50 (μM) |
|---|---|---|---|---|---|---|---|---|---|
| 10 | 0.08 | 0.47 | 0.09 | >50 | >50 | >45 | >50 | 3.0 | >50 |
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