Table 5. Pharmacokinetic Parameters of Compound 10.

	Mouse		Rat		Dog
PK Parameters	IV dose	PO dose	IV dose	PO dose	IV dose	PO dose
Dose (mg/kg)	2	10	0.5	5	1	2
Cl (mL/min/kg)	54		156		61
Vss (L/kg)	3.9		37		1.5
AUCN (μM·h)	1.38		0.118	0.188	0.61
T1/2 (h)	5.2		5.5		2.3
Cmax (μM)		0.48		0.050		0.071
Tmax (h)		0.25		0.38		0.75
F (%)		18		16		7.2
Plasma protein binding %	96.2		88.6		91.2

Plasma protein binding % in human plasma is 91.5.