Table 2. MICs^a of Analogues with Substitution at Orn.

		MRSAb				SAc	SFd	Enterococcus
no.	modification	SA11	SA14	SA86	SA88	ATCC29213	SF	ET6	ET60	ATCC29212
	daptomycin	0.5	0.5	0.5	0.25	0.25	4	2	2	4
4	Ala	0.5	0.25	0.5	1	0.5	4	2	1	4
10	Cyse	8	4	8	16	16	4	16	16	16
11	Asp	≥32	≥32	16	8	16	≥32	≥32	≥32	≥32
12	Glu	≥32	≥32	≥32	16	16	≥32	≥32	≥32	≥32
13	Phe	≥32	≥32	16	16	16	≥32	≥32	≥32	≥32
14	Gly	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
15	His	16	16	8	8	8	≥32	≥32	≥32	≥32
16	Ile	≥32	≥32	8	4	8	≥64	≥64	32	≥64
17	Lys	16	≥32	1	1	1	8	≥32	16	≥32
18	Leu	1	0.5	4	2	4	≥32	≥32	16	≥32
19	Met	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
20	Asn	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
21	Pro	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
22	Gln	≥32	≥32	4	4	4	≥32	≥32	≥32	≥32
23	Arg	8	16	2	1	2	8	≥32	16	≥32
24	Ser	4	4	2	1	2	4	≥32	≥32	≥32
25	Thr	16	16	2	2	2	≥32	≥32	≥32	≥32
26	Val	≥32	≥32	8	8	8	≥32	≥32	≥32	≥32
27	Trp	2	1	4	2	4	2	≥32	≥32	≥32
28	Tyr	1	0.5	4	4	1	≥32	≥32	16	≥32

^aUnits in μg/mL.

^bMethicillin-resistant S. aureus.

^cS. aureus.

^dStreptococcus faecalis.

^eIn dimeric form via disulfide bond.