Table 4. MIC^a of Analogues with Modification at the DXDG Conserved Motif.

		MRSAb				SAc	SFd	Enterococcus
no.	modification	SA11	SA14	SA86	SA88	ATCC29213	SF	ET6	ET60	ATCC29212
	daptomycin	0.5	0.5	0.5	0.25	0.25	4	2	2	4
31	Asp9 to Asn9	≥32	≥32	32	16	16	≥32	≥32	≥32	≥32
32	Asp9 to Glu9	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
33	Asp9 to d-Asp9	≥32	≥32	16	16	16	≥32	≥32	≥32	≥32
34	Asp9 to 3-mGlu9	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
35	Gly10 to Sar10	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
36	Asp7, Asp9 toAsn7, Asn9	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
37	Asp7, Asp9 toGlu7, Glu9	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32
38	Asp9, 3-mGlu12 to 3-mGlu9, Asp12	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32	≥32

^aUnits in μg/mL.

^bMethicillin-resistant S. aureus.

^cS. aureus.

^dStreptococcus faecalis.