Table 5. MICa of Analogues with Modification at Trp1.
| MRSAb |
SAc | SFd |
Enterococcus |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| no. | modification | SA11 | SA14 | SA86 | SA88 | ATCC29213 | SF | ET6 | ET60 | ATCC29212 |
| daptomycin | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 4 | 2 | 2 | 4 | |
| 39 | 1-Nap | 1 | 0.25 | 0.25 | 0.125 | 0.25 | 0.5 | 2 | 2 | 2 |
| 40 | Pyr | ≥32 | ≥32 | ≥32 | ≥32 | ≥32 | ≥32 | ≥32 | ≥32 | ≥32 |
| 41 | 2-Nap | 0.5 | 0.125 | 0.06 | 0.125 | 0.25 | 0.25 | 4 | 0.5 | 1 |
| 42 | TyrOMe | 16 | 4 | 2 | 2 | 2 | 8 | ≥32 | ≥32 | ≥32 |
Units in μg/mL.
Methicillin-resistant S. aureus.
S. aureus.
Streptococcus faecalis.
