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. 2020 Jun 3;11(7):1442–1449. doi: 10.1021/acsmedchemlett.0c00175

Table 5. MICa of Analogues with Modification at Trp1.

graphic file with name ml0c00175_0006.jpg

    MRSAb
SAc SFd Enterococcus
no. modification SA11 SA14 SA86 SA88 ATCC29213 SF ET6 ET60 ATCC29212
  daptomycin 0.5 0.5 0.5 0.25 0.25 4 2 2 4
39 1-Nap 1 0.25 0.25 0.125 0.25 0.5 2 2 2
40 Pyr ≥32 ≥32 ≥32 ≥32 ≥32 ≥32 ≥32 ≥32 ≥32
41 2-Nap 0.5 0.125 0.06 0.125 0.25 0.25 4 0.5 1
42 TyrOMe 16 4 2 2 2 8 ≥32 ≥32 ≥32
a

Units in μg/mL.

b

Methicillin-resistant S. aureus.

c

S. aureus.

d

Streptococcus faecalis.