Table 7. MICa of Analogues with Modification by Using Methylated Derivatives.
| MRSAb |
SAc | SFd |
Enterococcus |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| no. | modification | SA11 | SA14 | SA86 | SA88 | ATCC29213 | SF | ET6 | ET60 | ATCC29212 |
| daptomycin | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 4 | 2 | 2 | 4 | |
| 47 | Kyn-13 to Me-Kyn-13 (kynomycin) | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.5 | 1 | 1 | 1 |
| 48 | Trp-1 to 1-Me-Trp-1 | 2 | 0.5 | 0.5 | 0.25 | 0.5 | 0.5 | 1 | 1 | 2 |
| 49 | Gly-5 to Sar-5 | 0.5 | 0.25 | 0.5 | 0.5 | 0.5 | 2 | 8 | 4 | 8 |
Units in μg/mL, data from ref (23).
Methicillin-resistant S. aureus.
S. aureus.
Streptococcus faecalis.