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. 2020 Jun 3;11(7):1442–1449. doi: 10.1021/acsmedchemlett.0c00175

Table 7. MICa of Analogues with Modification by Using Methylated Derivatives.

    MRSAb
SAc SFd Enterococcus
no. modification SA11 SA14 SA86 SA88 ATCC29213 SF ET6 ET60 ATCC29212
  daptomycin 0.5 0.5 0.5 0.25 0.25 4 2 2 4
47 Kyn-13 to Me-Kyn-13 (kynomycin) 0.5 0.25 0.25 0.25 0.25 0.5 1 1 1
48 Trp-1 to 1-Me-Trp-1 2 0.5 0.5 0.25 0.5 0.5 1 1 2
49 Gly-5 to Sar-5 0.5 0.25 0.5 0.5 0.5 2 8 4 8
a

Units in μg/mL, data from ref (23).

b

Methicillin-resistant S. aureus.

c

S. aureus.

d

Streptococcus faecalis.