Table 3. Pharmacokinetic Parameters of 13 and 19 in Male SD Rats.
13 | 19 | |
---|---|---|
po dose (mg/kg) | 10 | 1 |
Cmax (ng/mL) | 2708 | 1839 |
AUC0–∞ (ng·h/mL) | 17813 | 23463 |
F (%) | 16 | 77 |
iv dose (mg/kg) | 0.5 | 1 |
Cmax (ng/mL) | 4908 | 12357 |
AUC0–∞ (ng·h/mL) | 5558 | 30430 |
CLtot (mL·h–1·kg–1) | 91 | 34 |
Vdss (mL/kg) | 197 | 249 |