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. 2020 Jun 4;11(7):1416–1420. doi: 10.1021/acsmedchemlett.0c00108

Table 3. Pharmacokinetic Parameters of 13 and 19 in Male SD Rats.

  13 19
po dose (mg/kg) 10 1
Cmax (ng/mL) 2708 1839
AUC0–∞ (ng·h/mL) 17813 23463
F (%) 16 77
iv dose (mg/kg) 0.5 1
Cmax (ng/mL) 4908 12357
AUC0–∞ (ng·h/mL) 5558 30430
CLtot (mL·h–1·kg–1) 91 34
Vdss (mL/kg) 197 249