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| progenitor 18 | macrocycle 19 | |
|---|---|---|
| in vivo Cl (mL min–1 kg–1) | 233 | 12.3 |
| Vdss (L kg–1) | 8.5 | 1.8 |
| half life (h) | 0.60 | 1.5 |
| predicted Fu (based on HSA, AGP, and CMR)24 | 0.40 | 0.06 |
| Clunbound (mL min–1 kg–1) | 587 | 192 |
