Table 1. NOS Inhibition% Given by Compounds 2–6, 9, 10, 17, 18, 23, and 24.
%inhibition
@ 1 μMa |
% inhibition @ 10 μMa | ||
---|---|---|---|
Cpd | iNOS | nNOS | eNOSa |
2 | 81 ± 0.35 | 47 ± 0.23 | 3 ± 0.01 |
3 | 85 ± 0.58 | 10 ± 0.06 | 0 ± 0.01 |
4 | 93 ± 0.27 | 0 ± 0.07 | 5 ± 0.02 |
5 | 86 ± 0.25 | 14 ± 0.08 | 62 ± 0.21 |
6 | 70 ± 0.23 | 0 ± 0.03 | 4 ± 0.05 |
9 | 100 ± 0.55 | 2 ± 0.08 | 14 ± 0.12 |
10 | 100 ± 0.44 | 13 ± 0.24 | 4 ± 0.02 |
17 | 100 ± 0.76 | 0 ± 0.03 | 0 ± 0.01 |
18 | 87 ± 0.33 | 97 ± 0.21 | 0 ± 0.01 |
23 | 84 ± 0.24 | 96 ± 0.11 | 0 ± 0.01 |
24 | 100 ± 0.69 | 0 ± 0.01 | 0 ± 0.01 |
Values given are mean ± SD of experiments performed in triplicate.