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. 2020 Jun 19;11(7):1470–1475. doi: 10.1021/acsmedchemlett.0c00285

Table 3. Potency and Selectivity of Compound 17 against Human NOS.

  IC50 (μM)a
Selectivity
Cpd hiNOS hnNOS heNOS nNOS/iNOS eNOS/iNOS
17 0.011 ± 0.02 6.2 ± 0.08 >10 563 >900
1400W 0.080 ± 0.02 7.8 ± 0.04 304 ± 2 72 3800
a

Values given are mean ± SD of experiments performed in triplicate at seven different concentrations.