Table 3. Potency and Selectivity of Compound 17 against Human NOS.
IC50 (μM)a |
Selectivity |
||||
---|---|---|---|---|---|
Cpd | hiNOS | hnNOS | heNOS | nNOS/iNOS | eNOS/iNOS |
17 | 0.011 ± 0.02 | 6.2 ± 0.08 | >10 | 563 | >900 |
1400W | 0.080 ± 0.02 | 7.8 ± 0.04 | 304 ± 2 | 72 | 3800 |
Values given are mean ± SD of experiments performed in triplicate at seven different concentrations.