Fig. 4. Interactions of naphthyridine-based INSTIs and HIV intasomes.

Schematic representation that recapitulates the receptor molecular environment and the water networks with which the naphthyridine scaffold ligands interact when coordinating the Mg²⁺ ions. The scheme summarizes interactions by their location with respect to the metal coordination plane of the naphthyridine scaffold (above, in-plane, and below). For clarity, the two waters coordinating the Mg²⁺ ions from above are not shown.