Table 2.
Difference in sensitivity for the receptor/agonist combinations with either Twitch2B or YC3.6 sensor transfected at DNA concentration of 8 ng/µL
| Receptor | Agonist | Response rangea of Twitch2B | Response rangea of YC3.6 | Fold increase in sensitivity | Reference EC50 values |
|---|---|---|---|---|---|
| TAS2R8 | Chloramphenicol | 3.9–125 µM | 31.2–500 µM | 8 | n.d. |
| Denatonium benzoate | 250–1000 µM | — | n.d. | ||
| TAS2R10 | Denatonium benzoate | 15.6–125 µM | 125–500 µM | 8 | 59 µM ± 30 (Born et al. 2013) |
| TAS2R14 | Picrotoxinin | 31.2–250 µM | 62.5–250 µM | 2 | 18 µM (Behrens et al. 2004) |
| TAS2R16 | D-salicin | 0.312–10 mM | 1.25–10 mM | 4 | 1.2 mM (Greene et al. 2011); 1.1 mM ± 0.3 (Bufe et al. 2002) |
| TAS2R38 PAV | PROP (6-n-propylthiouracil) | 10–20 µM | — | 2.1 µM (Meyerhof et al. 2011) | |
| TAS2R43 | Aristolochic acid | 62.5–500 nM | 250–500 nM | 4 | 81 nM ± 0.0008 (Kuhn et al. 2004) |
| TAS2R46 | Picrotoxinin | 62.5–250 µM | — | 70 µM ± 5.2 (Brockhoff et al. 2007) | |
| Chloramphenicol | 125–500 µM | — | n.d. | ||
| Denatonium benzoate | 62.5–125 µM | 250–500 µM | 4 | 240 µM ± 192 (Brockhoff et al. 2007) |
n.d., EC50 not determined, but activation published in Meyerhof et al. (2010).
aConcentration range in which an increasing response trend is observed.