Table 2.
The performance of various methods for distinguishing between the fatal cases and the survived patients
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy (%) |
|---|---|---|---|---|---|---|---|---|---|
| IL-2R (U/mL) | 1220 | 0.814 (0.755–0.874) | 41.18% (27.67–54.68%) | 92.15% (90.14–94.16%) | 28.00% (17.84–38.16%) | 95.48% (93.90–97.06%) | 5.25 (3.46–7.95) | 0.64 (0.51–0.80) | 88.63 |
| IL-6 (pg/mL) | 39.5 | 0.901 (0.860–0.942) | 68.63% (55.89–81.36%) | 90.41% (88.21–92.61%) | 34.65% (25.37–43.93%) | 97.49% (96.28–98.71%) | 7.15 (5.33–9.61) | 0.35 (0.23–0.52) | 88.90 |
| IL-8 (pg/mL) | 30 | 0.808 (0.738–0.879) | 54.90% (41.25–68.56%) | 90.26% (88.05–92.48%) | 29.47% (20.31–38.64%) | 96.43% (95.00–97.86%) | 5.64 (4.02–7.90) | 0.50 (0.37–0.68) | 87.82 |
| TNF-α (pg/mL) | 14.4 | 0.724 (0.644–0.804) | 33.33% (20.40–46.27%) | 90.12% (87.89–92.35%) | 20.00% (11.50–28.50%) | 94.80% (93.10–96.50%) | 3.37 (2.15–5.28) | 0.74 (0.61–0.90) | 86.20 |
| B cells (/μL) | 63 | 0.757 (0.685–0.828) | 39.22% (25.82–52.62%) | 90.70% (88.53–92.87%) | 23.81% (14.70–32.92%) | 95.27% (93.64–96.89%) | 4.22 (2.79–6.38) | 0.67 (0.54–0.84) | 87.14 |
| CD4+ T cells (/μL) | 323 | 0.906 (0.860–0.952) | 78.43% (67.14–89.72%) | 90.41% (88.21–92.61%) | 37.74% (28.51–46.96%) | 98.26% (97.24–99.28%) | 8.18 (6.24–10.72) | 0.24 (0.14–0.40) | 89.58 |
| CD8+ T cells (/μL) | 148 | 0.905 (0.857–0.953) | 72.55% (60.30–84.80%) | 90.99% (88.85–93.13%) | 37.37% (27.84–46.90%) | 97.81% (96.68–98.95%) | 8.05 (6.02–10.77) | 0.30 (0.19–0.47) | 89.72 |
| NK cells (/μL) | 81 | 0.888 (0.834–0.941) | 66.67% (53.73–79.60%) | 90.55% (88.37–92.74%) | 34.34% (24.99–43.70%) | 97.34% (96.10–98.59%) | 7.06 (5.22–9.54) | 0.37 (0.25–0.54) | 88.90 |
| Prediction model | 0.075 | 0.956 (0.928–0.984) | 90.20% (82.03–98.36%) | 90.26% (88.05–92.48%) | 40.71% (31.65–49.77%) | 99.20% (98.50–99.90%) | 9.26 (7.25–11.83) | 0.11 (0.05–0.25) | 90.26 |
AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval; IL-2R, interleukin-2 receptor; IL-6, interleukin-6; IL-8, interleukin-8; TNF-α, tumor necrosis factor-α