Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 19;112(7):728–736. doi: 10.1093/jnci/djz206

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Figure 1. — Intrinsic subtype distribution by estrogen receptor (ER) category in Carolina Breast Cancer Study phases I, II, and III. ER-negatives and ER-borderlines had a statistically significantly higher frequency of HER2-enriched (17.7% ER-negative, relative frequency difference [RFD] = +67.5%, 95% confidence interval [CI] = 58.6 to 76.4, P < .001; 14.3% ER-borderline, RFD = +27.2%, 95% CI = 12.2 to 42.2, P <.001; two-sided χ² test) and basal-like subtypes (71.7% ER-negative, RFD = +80.3%, 95% CI = 76.1 to 84.4, P <.001; 41.8% ER-borderline, RFD = +37.7%, 95% CI = 27.1 to 48.4, P <.001; two-sided χ² test) relative to ER-positive (2.7% HER2-enriched, 5.1% basal-like).