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. 2019 Oct 29;112(7):708–719. doi: 10.1093/jnci/djz208

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Therapeutic immune targets according to triple-negative breast cancer (TNBC) molecular and tumor immune microenvironment (TIME) subtypes. Associations of 44 immune genes corresponding to immunomodulatory targets with TNBC molecular (A) and TIME (B) subtypes. A logistic regression model was used to evaluate associations between each gene expression with each subtype. P values were obtained from parametric Mann-Whitney U tests and corrected for multi testing. Only statistically significant associations are shown (FDR ≤ .05), with negative and positive associations represented in red and green, respectively. The left half-circle and the right half-circle represent cohorts A and B, respectively. BL = Basal-like; FI = Fully-inflammed; IM = Immunomodulatory; LAR = Luminal androgen receptor; M = Mesenchymal; MR = Margin restricted; MSL = Mesenchymal stem-like; SR = Stroma restricted.