Table 2.
Cox regression analysis for tumor and normal (T/N) ratio of telomere fractions and survival status for patients with hematologic cancers and brain and solid tumors
| Tumor type | Hematologic (n = 239) |
Brain (n = 148) |
Solid (n = 101) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P * | HR | 95% CI | P * | HR | 95% CI | P * | |
| Age at diagnosis, y | |||||||||
| < 5 | 0.02 | 0.00 to 0.14 | <.001 | 0.02 | 0.00 to 0.14 | <.001 | 0.11 | 0.02 to 0.63 | .01 |
| 5–9 | 0.15 | 0.03 to 0.77 | .02 | 0.04 | 0.01 to 0.24 | <.001 | 0.16 | 0.04 to 0.65 | .01 |
| 10–14 | 0.45 | 0.10 to 2.01 | .29 | 0.30 | 0.07 to 1.31 | 0.11 | 0.30 | 0.11 to 0.80 | .02 |
| 15+ | 1.00 | (Referent) | 1.00 | (Referent) | 1.00 | (Referent) | |||
| Female vs male | 0.95 | 0.49 to 1.82 | .87 | 1.24 | 0.66 to 2.31 | 0.50 | 0.83 | 0.40 to 1.71 | .62 |
| Race | |||||||||
| White | 1.00 | (Referent) | 1.00 | (Referent) | 1.00 | (Referent) | |||
| Black | 1.09 | 0.49 to 2.42 | .83 | 1.44 | 0.70 2.98 | 0.32 | 1.86 | 0.81 to 4.28 | .14 |
| Other | 0.68 | 0.16 to 3.00 | .61 | 0.96 | 0.28 to 3.32 | 0.95 | 0.99 | 0.22 to 4.58 | .99 |
| Telomere ratio | 0.81 | 0.27 to 2.39 | .70 | 2.18 | 1.37 to 3.46 | 0.001 | 1.07 | 0.61 to 1.87 | .82 |
*
P values are from two-sided Wald tests. HR = hazard ratio; CI = confidence interval; Referent = reference category.