Figure 2. MRI of the index patient (II:3).

T2-weighted MRI at ages 23 days (A–D), 2 months (F–I), and 4 years (K–N) and T1 at corresponding age (E, J, and O). Peripheral white matter in the parietal (*) compared with frontal (°) lobes shows increased signal at 23 days (B and C) that persists in parietal lobes at 4 years (M). At age 4 years, subcortical frontal and temporal white matter (arrow heads) (L–N) shows persistant high signal for age when it should have resolved by age 3 years.