Table 4.
Ordinal Regression Results: Association with Anticholinergic Burden and Phenotype Versus Healthy Controls
| Models | Phenotypes (MMSE and CHS) | (n) | ||||
| 1 | Cognition | |||||
| Moderate Cognitive Impairment | 501 | |||||
| Severe Cognitive Impairment | 101 | |||||
| 2 | Frailty | |||||
| Frail | 88 | |||||
| Prefrail | 507 | |||||
| 3 | Cognitive Frailty | |||||
| Moderate Cognitive Impairment and Frail | 55 | |||||
| Moderate Cognitive Impairment and Prefrail | 217 | |||||
| Severe Cognitive Impairment and Frail | 11 | |||||
| Severe Cognitive Impairment and Prefrail | 76 | |||||
| Models | Phenotype | Beta Coef | SE | Odds Ratio | 95% CI | p-value |
| 1 | Cognitive Impairment | 0.19 | 0.07 | 1.21 | 1.07–1.37 | <.001 |
| 2 | Frailty | 0.29 | 0.06 | 1.33 | 1.87–1.50 | <.001 |
| 3 | Cognitive Frailty | 0.31 | 0.06 | 1.36 | 1.21–1.54 | <.001 |
CHS = Cardiovascular Heart Study; CI = Confidence interval; MMSE = Mini-Mental State Examination.