Figure 4.

Multivariable associations between biological system trajectories and cardiovascular disease events after examination eight (n = 2,270). All hazard ratios are adjusted for age at examination eight and sex. Number of events and persons may not add up as they are based on the means of 10 imputed datasets. BMD, CRP, eGFR, FEV1/FVC, FVC, grip strength, heart rate, LVMI, and MMSE did not reach the entry threshold of p < .05 and were not included in the multivariable model. The biological systems in the multivariable model are reported in the order of significance. BMI = Body mass index; CI = Confidence interval; HR = Hazard ratio; HbA1c = Glycated hemoglobin; TC = Total cholesterol; HDL = High-density lipoprotein cholesterol.