Table 1.
Criteria for defining cytokine release syndrome in COVID-19.
| One or more of the following criteria should be presenta |
| C-reactive protein >100 or >50 mg/L but doubled in the past 48 h |
| lymphocyte count <0.6 × 109/L |
| Serum Interleukin-6 (IL-6) ≥ 3× upper normal limit |
| Ferritin >300 ug/L (or surrogate) with doubling within 24 h |
| Ferritin >600 ug/L at presentation and LDH >250 U/L |
| Elevated D-dimer (>1 mcg/mL) |
Abbreviations: CRS = cytokine release syndrome, LDH = lactate dehydrogenase.
a
We define as low risk for developing CRS the presence of one criterion, moderate risk the presence of two to three criteria and high risk the presence of more than three criteria.