FIG 1.

Effects of GH12 on the cariogenic properties of the human dental plaque-derived multispecies biofilms. (A) Quantification of water-insoluble EPS synthesis. (B) Quantification of lactic acid production. (C) pH of the culture medium. All the experiments were repeated at least three times. All values are presented as the mean ± SD. Statistical analyses were performed using one-way ANOVA and Tukey’s HSD test. Different superscript letters indicate significant differences (P < 0.05). *, the pH values in the group treated with 64-mg/liter GH12 were significantly different from those in every other group (P < 0.05).