FIG 3.

Effects of GH12 on the microbiota of the human dental plaque-derived multispecies biofilms. (A) Shannon index and Chao index at the OTU level. Values are presented as the mean ± SD (n = 8). Statistical analyses were performed using Student’s t test. ns, not significant (P > 0.05). (B) PCA at the OTU level (n = 8). (C) Rank of distance based on the Bray-Curtis distance between or within groups. Values are presented as the mean ± SD (n = 8). Statistical analyses were performed using ANOSIM. (D) Relative abundance of species-level taxa in the DDW group and the GH12 group. (E) Proportions of the top 10 most abundant species in the DDW group and the GH12 group. Values are presented as the mean ± SD (n = 8). Statistical analyses were performed using the Wilcoxon rank-sum test. *, P < 0.05; ns, not significant (P > 0.05); _p_, phylum; _g_, genus.