Table 3.
Calculated Crude and Adjusted (Age, Sex, Race/Ethnicity) CVD IRRs by Cancer Type and CVRF (Hypertension, Diabetes, Dyslipidemia) for Cancer Survivors and Comparison Controls
| Cancer Type | Crude IRR | Adjusted IRR | ||||
|---|---|---|---|---|---|---|
| IRR | 95% CI | P | IRR | 95% CI | P | |
| Breast | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 2.41 | 2.22 to 2.62 | < .01 | 1.79 | 1.64 to 1.95 | < .01 |
| Noncancer comparison, ≥ 2 CVRF | 1.30 | 1.19 to 1.43 | < .01 | 1.33 | 1.21 to 1.46 | < .01 |
| Cancer survivor, ≥ 2 CVRF | 2.52 | 2.28 to 2.78 | < .01 | 1.87 | 1.69 to 2.07 | < .01 |
| Kidney | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 1.53 | 1.20 to 1.93 | < .01 | 1.15 | 0.90 to 1.46 | .27 |
| Noncancer comparison, ≥ 2 CVRF | 1.01 | 0.75 to 1.36 | .96 | 1.08 | 0.80 to 1.46 | .61 |
| Cancer survivor, ≥ 2 CVRF | 2.19 | 1.71 to 2.80 | < .01 | 1.83 | 1.42 to 2.35 | < .01 |
| Lung and bronchus | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 1.74 | 1.45 to 2.08 | < .01 | 1.46 | 1.22 to 1.75 | < .01 |
| Noncancer comparison, ≥ 2 CVRF | 1.94 | 1.57 to 2.40 | < .01 | 2.04 | 1.64 to 2.52 | < .01 |
| Cancer survivor, ≥ 2 CVRF | 2.49 | 1.95 to 3.17 | < .01 | 2.29 | 1.79 to 2.92 | < .01 |
| Multiple myeloma | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 1.47 | 1.07 to 2.01 | .02 | 1.28 | 0.93 to 1.77 | .13 |
| Noncancer comparison, ≥ 2 CVRF | 1.70 | 1.17 to 2.47 | .01 | 1.74 | 1.20 to 2.53 | < .01 |
| Cancer survivor, ≥ 2 CVRF | 2.74 | 1.92 to 3.91 | < .01 | 2.59 | 1.81 to 3.71 | < .01 |
| Non-Hodgkin lymphoma | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 1.92 | 1.59 to 2.31 | < .01 | 1.45 | 1.20 to 1.75 | < .01 |
| Noncancer comparison, ≥ 2 CVRF | 1.42 | 1.15 to 1.75 | < .01 | 1.39 | 1.13 to 1.72 | < .01 |
| Cancer survivor, ≥ 2 CVRF | 2.62 | 2.09 to 3.28 | < .01 | 2.12 | 1.69 to 2.65 | < .01 |
| Ovary | ||||||
| Noncancer comparison, < 2 CVRF | 1.00 (Ref) | — | 1.00 (Ref) | — | ||
| Cancer survivor, < 2 CVRF | 2.11 | 1.49 to 2.98 | < .01 | 1.47 | 1.03 to 2.09 | .03 |
| Noncancer comparison, ≥ 2 CVRF | 1.36 | 0.94 to 1.96 | .11 | 1.54 | 1.06 to 2.23 | .02 |
| Cancer survivor, ≥ 2 CVRF | 2.83 | 1.90 to 4.22 | < .01 | 2.00 | 1.33 to 3.00 | < .01 |
Abbreviations: CVD, cardiovascular disease; CVRF, cardiovascular risk factors; IRR, incidence rate ratio; Ref, reference.