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. 2020 Jul 10;8:e9478. doi: 10.7717/peerj.9478

Table 2. Abbreviations and statistical summary of enriched fractions of the Sixty-four cell types.

Full name Abbreviations Group TumorN = 1, 092(Mean ± SD) NormalN = 112(Mean ± SD) Paired TumorN = 112(Mean ± SD) P value P value(paired)
Activated dendritic cells aDC Immune 0.116 ± 0.110 0.016 ± 0.045 0.103 ± 0.104 <0.001 <0.001
B-cells / Immune 0.031 ± 0.085 0.004 ± 0.039 0.021 ± 0.052 <0.001 <0.001
Basophils / Immune 0.078 ± 0.056 0.058 ± 0.040 0.071 ± 0.054 <0.001 0.077
CD4+ naive T-cells / Immune 0.010 ± 0.029 0.003 ± 0.015 0.008 ± 0.020 0.009 0.004
CD4+ T-cells / Immune 0.003 ± 0.010 0.000 ± 0.003 0.001 ± 0.004 0.101 0.036
Central memory CD4+ T Cell CD4+ Tcm Immune 0.009 ± 0.015 0.016 ± 0.019 0.003 ± 0.007 0.006 <0.001
Effector memory CD4+ T cell CD4+ Tem Immune 0.013 ± 0.022 0.000 ± 0.002 0.010 ± 0.018 <0.001 <0.001
CD4+ memory T-cells Immune 0.007 ± 0.017 0.000 ± 0.004 0.007 ± 0.012 <0.001 <0.001
CD8+ naive T-cells / Immune 0.012 ± 0.011 0.005 ± 0.007 0.011 ± 0.010 <0.001 <0.001
CD8+ T-cells / Immune 0.018 ± 0.039 0.006 ± 0.016 0.016 ± 0.032 <0.001 0.001
Central memory CD8+ T Cell CD8+ Tcm Immune 0.026 ± 0.049 0.005 ± 0.015 0.027 ± 0.046 <0.001 <0.001
Effector memory CD8+ T cell CD8+ Tem Immune 0.001 ± 0.007 0.000 ± 0.000 0.000 ± 0.002 0.805 0.608
Conventional dendritic cells cDC Immune 0.037 ± 0.046 0.072 ± 0.057 0.040 ± 0.043 <0.001 <0.001
Class-switched memory B-cells / Immune 0.026 ± 0.031 0.002 ± 0.014 0.020 ± 0.023 <0.001 <0.001
Dendritic cells DC Immune 0.005 ± 0.011 0.005 ± 0.011 0.004 ± 0.008 0.826 0.927
Eosinophils / Immune 0.000 ± 0.001 0.000 ± 0.000 0.000 ± 0.001 0.737 0.763
Immature dendritic cells iDC Immune 0.042 ± 0.073 0.167 ± 0.171 0.047 ± 0.053 <0.001 <0.001
Macrophages / Immune 0.038 ± 0.036 0.008 ± 0.023 0.038 ± 0.034 <0.001 <0.001
Inflammatory (M1) macrophages Macrophages M1 Immune 0.022 ± 0.027 0.003 ± 0.010 0.019 ± 0.027 <0.001 <0.001
Reparative (M2) macrophages Macrophages M2 Immune 0.031 ± 0.021 0.030 ± 0.034 0.031 ± 0.017 0.001 0.003
Mast cells / Immune 0.024 ± 0.012 0.015 ± 0.008 0.025 ± 0.010 <0.001 <0.001
Memory B-cells / Immune 0.006 ± 0.028 0.001 ± 0.011 0.003 ± 0.014 <0.001 0.083
Monocytes / Immune 0.004 ± 0.012 0.003 ± 0.013 0.004 ± 0.011 0.007 0.040
naive B-cells / Immune 0.004 ± 0.016 0.001 ± 0.009 0.003 ± 0.009 <0.001 0.004
Neutrophils / Immune 0.000 ± 0.001 0.003 ± 0.005 0.000 ± 0.000 <0.001 <0.001
Nature killer cells NK cells Immune 0.000 ± 0.002 0.000 ± 0.000 0.000 ± 0.001 0.342 0.759
Natural killer T cells NKT Immune 0.061 ± 0.039 0.028 ± 0.036 0.043 ± 0.028 <0.001 <0.001
Plasmacytoid dendritic cells pDC Immune 0.008 ± 0.019 0.000 ± 0.000 0.007 ± 0.017 <0.001 0.004
Plasma cells / Immune 0.019 ± 0.018 0.001 ± 0.003 0.015 ± 0.012 <0.001 <0.001
pro B-cells / Immune 0.009 ± 0.017 0.000 ± 0.000 0.006 ± 0.013 <0.001 <0.001
Gamma delta T cells Tgd cells Immune 0.003 ± 0.009 0.000 ± 0.000 0.004 ± 0.011 <0.001 0.003
Regulatory T cells Tregs Immune 0.012 ± 0.016 0.004 ± 0.009 0.013 ± 0.016 <0.001 <0.001
Type 1 T helper (Th1) cells Th1 cells Immune 0.133 ± 0.092 0.014 ± 0.026 0.101 ± 0.067 <0.001 <0.001
Type 2 T helper (Th2) cells Th2 cells Immune 0.075 ± 0.096 0.002 ± 0.007 0.082 ± 0.091 <0.001 <0.001
Astrocytes / Others 0.076 ± 0.069 0.110 ± 0.065 0.081 ± 0.064 <0.001 <0.001
Epithelial cells / Others 0.365 ± 0.092 0.277 ± 0.146 0.354 ± 0.089 <0.001 <0.001
Hepatocytes / Others 0.001 ± 0.002 0.005 ± 0.003 0.002 ± 0.002 <0.001 <0.001
Keratinocytes / Others 0.047 ± 0.038 0.065 ± 0.037 0.046 ± 0.038 <0.001 <0.001
Melanocytes / Others 0.010 ± 0.008 0.008 ± 0.008 0.010 ± 0.009 0.011 0.162
Mesangial cells / Others 0.014 ± 0.015 0.034 ± 0.013 0.015 ± 0.015 <0.001 <0.001
Neurons / Others 0.004 ± 0.008 0.004 ± 0.002 0.004 ± 0.006 <0.001 <0.001
Sebocytes / Others 0.016 ± 0.019 0.009 ± 0.009 0.017 ± 0.024 <0.001 <0.001
Common lymphoid progenitor CLP Stem 0.039 ± 0.026 0.013 ± 0.015 0.041 ± 0.026 <0.001 <0.001
Common myeloid progenitor CMP Stem 0.001 ± 0.003 0.003 ± 0.004 0.001 ± 0.003 <0.001 0.008
Granulocyte-macrophage progenitor GMP Stem 0.002 ± 0.006 0.002 ± 0.006 0.002 ± 0.008 0.001 0.025
Hematopoietic stem cells HSC Stem 0.150 ± 0.110 0.492 ± 0.191 0.174 ± 0.125 <0.001 <0.001
Megakaryocytes / Stem 0.004 ± 0.004 0.021 ± 0.009 0.005 ± 0.005 <0.001 <0.001
Multipotent progenitors MPP Stem 0.00 ± 0.001 0.000 ± 0.000 0.000 ± 0.000 <0.001 0.027
Erythrocytes / Stem 0.000 ± 0.000 0.000 ± 0.000 0.000 ± 0.000 0.471 0.306
Megakaryocyte-erythroid progenitor MEP Stem 0.035 ± 0.030 0.011 ± 0.017 0.027 ± 0.022 <0.001 <0.001
Platelets / Stem 0.000 ± 0.002 0.000 ± 0.001 0.000 ± 0.001 0.062 0.334
Adipocytes / Stromal 0.050 ± 0.088 0.382 ± 0.207 0.063 ± 0.102 <0.001 <0.001
Chondrocytes / Stromal 0.035 ± 0.037 0.053 ± 0.022 0.040 ± 0.038 <0.001 <0.001
Endothelial cells / Stromal 0.058 ± 0.056 0.209 ± 0.104 0.066 ± 0.059 <0.001 <0.001
Fibroblasts / Stromal 0.058 ± 0.068 0.172 ± 0.078 0.063 ± 0.074 <0.001 <0.001
Lymphatic endothelial cells ly Endothelial cells Stromal 0.020 ± 0.027 0.110 ± 0.071 0.021 ± 0.025 <0.001 <0.001
Mesenchymal stem cells MSC Stromal 0.281 ± 0.144 0.019 ± 0.054 0.252 ± 0.139 <0.001 <0.001
Microvascular endothelial cells mv Endothelial cells Stromal 0.032 ± 0.032 0.104 ± 0.062 0.029 ± 0.028 <0.001 <0.001
Myocytes / Stromal 0.004 ± 0.010 0.009 ± 0.042 0.005 ± 0.008 0.012 0.387
Osteoblast / Stromal 0.025 ± 0.031 0.005 ± 0.013 0.018 ± 0.024 <0.001 <0.001
Pericytes / Stromal 0.053 ± 0.052 0.027 ± 0.035 0.057 ± 0.055 <0.001 <0.001
Preadipocytes / Stromal 0.024 ± 0.040 0.179 ± 0.090 0.032 ± 0.045 <0.001 <0.001
Skeletal muscle / Stromal 0.001 ± 0.011 0.010 ± 0.101 0.001 ± 0.003 0.442 0.365
Smooth muscle / Stromal 0.133 ± 0.091 0.125 ± 0.067 0.175 ± 0.088 0.345 <0.001
ImmuneScore / / 0.082 ± 0.103 0.029 ± 0.049 0.074 ± 0.079 <0.001 <0.001
StromaScore / / 0.083 ± 0.088 0.382 ± 0.174 0.096 ± 0.097 <0.001 <0.001