Table 4. Evaluation of renal histopathology after administration of succinic acid.

Parameter	SH	12.5Tox	25Tox	50Tox	IR	12.5+IR	25+IR	50+IR
Tubular Necrosis	0.00 (0.00–0.00)	0.00 (0.00–0.75)	0.00 (0.00–0.00)	0.00 (0.00–0.75)	3.50 (3.00-4.00)*	3.00 (2.50–3.50)	3.50 (3.00–4.00)	4.00 (3.75-4.00)
Acidophilic Casts	0.00 (0.00–0.50)	0.00 (0.00–0.00)	0.00 (0.00–0.75)	0.00 (0.00–0.00)	2.00 (2.00–3.00)	2.00 (1.50–3.00)	3.00 (2.75–3.25)	2.00 (2.00-2.50)
Vascular Congestion	1.00 (0.75–2.00)	1.00 (0.25–1.75)	0.50 (0.00–1.00)	1.00 (0.25–1.75)	1.50 (0.00–3.00)	2.00 (1.00–2.00)	1.50 (0.75–3.25)	3.00 (1.50-4.00)

Notes.

Kruskal-Wallis test, Dunn post hoc test. Values expressed as median (interquartile range). The comparisons were between the 12.5Tox, 25Tox, and SH groups, and between the SH, 12.5+IR, 25+IR, and IR groups. Significant differences when comparing IR vs. SH group: * p = 0.0297.