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. 2020 Jul;41(7):1293–1301. doi: 10.3174/ajnr.A6632

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© 2020 by American Journal of Neuroradiology

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FIG 1. — GABA, Glx, and creatine measurements in the anterior cingulate cortex. GABA and single-voxel ¹H-MR spectroscopy with TE = 135 ms are obtained from a voxel volume of 26.25 mL (voxel dimensions, 3.5 × 3.0 × 2.5 cm) in the anterior cingulate cortex. The volume fractions of brain parenchyma and gray matter in the MR spectroscopy voxels are obtained from T1 MPRAGE segmentation using the SPM program. Last, GABA/Cr and Glx/Cr are adjusted by multiplying brain parenchymal and gray matter volume fractions for each individual.