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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2020 Mar;40:1–12. doi: 10.1200/EDBK_280807

Table 1.

Phase II trials to determine pCR and MPR after neoadjuvant ICI or ICI plus chemotherapy in patients with resectable and operable stage I-III lung cancers.

Author(s) Agent(s) MPR% (95% CI) pCR% (95% CI)
Johns Hopkins University/Memorial Sloan Kettering
N=21
Forde and Chaft(10) Nivolumab 43% (21 to 66) 14% (4 to 34)
LCMC3
Lung Cancer Mutation Consortium - USA
N=82
Kwiatkowski(12) Atezolizumab 18% (11 to 28) 5% (2 to 12)
NEOSTAR
MD Anderson
N=44
Cascone(13) Nivolumab + Ipilimumab 25% (14 to 40) 18% (9 to 32)
NADIM
Spanish Lung Cancer Group
N=30
Provencio(14) Nivolumab + Paclitaxel Carboplatin 80% (64 to 91) 75% (4 to 76)
Columbia University New York/MGH
N=30
Shu(11) Atezolizumab + Paclitaxel Carboplatin 57% (36 to 76) 33% (18 to 52)
Duke/Dartmouth/Mayo
N=25
Ready(15) Pembrolizumab 28% (12 to 49) 8% (1 to 26)