Table 5.

Predicted hazard ratios (with 95% CIs) and P values at the actual, target, and double target sample sizes using 50,000 bootstrap samples based on the reconstructed data from the second figure in Wang et al [13].

Sample size	Sample size in each arm		Unconditional prediction		Conditional prediction
	Remdesivir, n	Placebo, n	HRa (95% CI)	P value	HR (95% CI)	P value
Actual	158	78	1.23 (0.87-1.75)	.24	N/Ab	N/A
Target	302	151	1.24 (0.96-1.60)	.10	1.24 (1.03-1.48)	.02
Target×2	604	302	1.24 (1.03-1.48)	.02	1.24 (1.06-1.44)	.01

^aHR: hazard ratio.

^bNot applicable.