Fig 7. Administration of miR-223 over-expressed macrophages attenuates sepsis in LPS injection mouse model.

The characteristics of LPS injection mice after the administration with IL-4-activated-macrophages without gene over-expression (PBS-LPS) or with control mimic over-expression (Ctl mimic-LPS) or with miR-223 over-expression (miR-223-LPS) as evaluated by serum creatinine (A), aspartate transaminase (B), alanine transaminase (C), blood leukocyte evaluation (D-F) and serum cytokines (G-I) are demonstrated (n = 5-7/ group). Of note, only the control mice injected with phosphate buffer solution (PBS) group without LPS stimulation (PBS-PBS) is presented, but not Ctl mimic-PBS and miR-223-PBS, due to the similar values among these 3 control groups.