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Heart failure rate in different age groups of mice after 2-week TAC.
| Age (week) | C57BL/6J | C57BL/6N | P value |
|---|---|---|---|
| 8 | 20% (2/10) | 25% (3/12) | 1.000 |
| 10 | 17% (1/6) | 50% (3/6) | 0.546 |
| 12 | 20% (1/5) | 100% (5/5) | 0.048 |
| P value | 1.000 | 0.018 |
Heart failure with reduced systolic function was defined as having dyspnea, body weight loss (approximately 10% decrease), increased wet lung weight and reduced fractional shortening on echocardiography compared with sham controls.
