Table 1. Initial Front Pocket Studies.

^aKinase activity was measured by Caliper assay.

^bLTA-induced IL6 assay. Values represent mean IC₅₀ ± SD. All compounds were tested in duplicate unless otherwise noted.

^cLiver microsomal stability assays were typically single determinations.

^dLCK IC₅₀/IRAK4 IC₅₀.

^eNT, not tested.