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| compd | Caco-2 (nm/s) | dose, mg/kg (iv/po) | CL (mL·min–1·kg–1) | Vss (L/kg) | T1/2 (h) | AUC (μM·h) (iv/po) | F% |
|---|---|---|---|---|---|---|---|
| 12 | 81 | 2/10 | 47 | 2.1 | 2.2 | 1.6/3.3 | 40 |
| 18 | 38 | 2/3 | 14 | 3.2 | 3.6 | 4.7/4.6 | 65 |
| 20 | 69 | 2/2 | 33 | 3 | 2 | 2.4/0.9 | 36 |
| 21 | 215 | 2/5 | 15 | 2 | 1.4 | 5/24 | >100 |
