Table 3.
Comparison of model fit for TTE-derived Pheno-groupings versus Heart Failure Index score for HF Hospitalization
| Outcome | Harrell’s C-statistic (95% CI) | Integrated Discrimination Index (95%CI) |
|---|---|---|
| HF hospitalization | ||
| 0. Reference model* | 0.81 (0.78–0.84) | reference |
| 1. Reference + HFI | 0.82 (0.79–0.85), p=0.053† | +6.4% (1.5%, 12.5%), p=0.033† |
| 2. Reference + Phenogroup | 0.83 (0.80–0.85), p=0.025‡ | +5.1% (2.0%, 9.3%), p=0.007‡ |
| 1 vs. 2. Ref. + HFI vs. Ref. + Phenogroup | p=0.69 | −1.2% (−6.3% 4.0%), p=0.69 |
*
Reference model includes demographics (age, sex, race, body mass index), comorbidities (current smoking, diabetes, history of heart failure, history of myocardial infarction, history of angina or revascularization), laboratory values (total cholesterol, LDL, eGFR, NT-proBNP, hscTroponin T), and medication use (antihypertensive therapy and aspirin)
†
p-value for model 1 vs. 0;
‡
p-value for model 2 vs. 0
Abbreviations. TTE = transthoracic echocardiography; CI = confidence interval.