Fig. 10.

Schematic depicting role of LC3B during PEDV infection. DON exposure activates p38 signaling and triggers a complete autophagy in PEDV-infected IPEC-J2 cells. Approximately 2 hrs post-infection, LC3B induces occludin internalization to promote PEDV entry through its role as a positive regulator of autophagy. Later in infection (24 hpi.), the up-regulation of LC3B by DON contributes PEDV to escape innate immune via inhibiting the STING signaling phosphorylation, leading to production of large amounts of virus.