Table 2. Comparison of TcMAC21 and other mouse models of DS.
| Issues | TcMAC21 | Tc1 | Ts65Dn | Ts1Cje | Dp(16)1Yey/+ or Dp1Tyb | Dp(10)1Yey/+; Dp(16)1Yey/+; Dp(17)1Yey/+ |
|---|---|---|---|---|---|---|
| Mosaicism | No | Yes | No | No | No | No |
| Freely segregating chromosome | Yes | Yes | Yes | No | No | No |
| Trisomic HSA21q PCG/orthologs (% of 213 HSA21q) |
199 (93.4%) |
158 (74.2%) |
110 (51.6%) |
68 (31.9%) |
122 (57.3%) |
180 (40;122;18) (84.5%) |
| Trisomic HSA21q PCG/orthologs, excluding KRTAPs | 150 | 109 | 92 | 68 | 104 | 160 |
| * Trisomic mouse PCGs with no human ortholog | 0 | 0 | 7 | 7 | 10 | 12 |
| † Trisomic or monosomic PCGs that are not HSA21 orthologs | 0 | 0 | Trisomic ~44 MMU17 |
Monosomic ~ 7 MMU12 |
0 | 0 |
*Refer to data file S1A for the name and location of each mouse PCG conserved with Hsa21 (MMU10, 16, 17). Gene annotation is based on ‘GRCh38, P12’ and ‘GRCm.P6’.
†The reference of the translocation breakpoints of Ts65Dn and Ts1Cje is “Duchon A, Raveau M, Chevalier C, Nalesso V, Sharp AJ, Herault Y. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome. Mamm Genome. 2011;22(11, 12):674–684.’ The number of genes is based on ‘GRCm.P6’.