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. Author manuscript; available in PMC: 2020 Jul 13.
Published in final edited form as: J Am Chem Soc. 2019 Jan 14;141(4):1735–1741. doi: 10.1021/jacs.8b12493

Figure 4.

Figure 4.

(a) Overlay of the all-trans-retinal/M1-L121E complex in the dark (green) and after laser irradiation followed by incubation in the dark (25 min, orange) highlighting the structural similarity of the chromophore before and after a complete photocycle. (b) Overlay of the all-trans-retinal/M1-L121E complex in the dark (green) with the 13-cis-retinal/M1-L121E:A32Y complex. (c) Aromatic residues located in the binding pocket of 13-cis-bound M1-L121E:A32Y. (d) Bacteriorhodopsin (PDB code 1C3W) binding pocket where the chromophore is sandwiched with aromatic residues.